DNA photocleavage in anaerobic conditions by a Ru(ii) complex: a new mechanism

[Ru(bpy)2(py-SO3)](+) (bpy = 2,2'-bipyridine and py-SO3 = pyridine-2-sulfonate) was found to undergo py-SO3 dissociation upon visible light irradiation (≥470 nm) via Ru-O homolysis, producing reactive free radical species, and is thus able to not only photobind but also photocleave DNA in hypox...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (2), p.428-430
Hauptverfasser:	Zheng, Yue, Zhou, Qianxiong, Lei, Wanhua, Hou, Yuanjun, Li, Ke, Chen, Yongjie, Zhang, Baowen, Wang, Xuesong
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - analogs & derivatives 2,2'-Dipyridyl - chemistry 2,2'-Dipyridyl - pharmacology Anaerobic conditions Anaerobiosis Deoxyribonucleic acid DNA - chemistry DNA Cleavage - drug effects Free radicals Free Radicals - chemistry Light Light irradiation Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Photolysis - drug effects Sulfonic Acids - chemistry Sulfonic Acids - pharmacology
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Beschreibung
Zusammenfassung:	[Ru(bpy)2(py-SO3)](+) (bpy = 2,2'-bipyridine and py-SO3 = pyridine-2-sulfonate) was found to undergo py-SO3 dissociation upon visible light irradiation (≥470 nm) via Ru-O homolysis, producing reactive free radical species, and is thus able to not only photobind but also photocleave DNA in hypoxic conditions.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c4cc06552b