Probing structural changes of self assembled i-motif DNA

Probing structural changes of self assembled i-motif DNA

We report an i-motif structural probing system based on Thioflavin T (ThT) as a fluorescent sensor. This probe can discriminate the structural changes of RET and Rb i-motif sequences according to pH change.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-03, Vol.51 (18), p.3747-3749
Hauptverfasser: Lee, Il Joon, Patil, Sachin P, Fhayli, Karim, Alsaiari, Shahad, Khashab, Niveen M
Format: Artikel
Sprache:eng
Schlagworte:
Biosensing Techniques
Circular Dichroism
Deoxyribonucleic acid
Fluorescence
Fluorescent Dyes - analysis
Hydrogen-Ion Concentration
Nucleotide Motifs
Proto-Oncogene Proteins c-ret - genetics
Retinoblastoma Protein - genetics
Sensors
Spectrometry, Fluorescence
Thiazoles - analysis
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Beschreibung
Zusammenfassung:We report an i-motif structural probing system based on Thioflavin T (ThT) as a fluorescent sensor. This probe can discriminate the structural changes of RET and Rb i-motif sequences according to pH change.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06824f