Inhibited fragmentation of mAbs in buffered ionic liquids

Inhibited fragmentation of mAbs in buffered ionic liquids

We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-05, Vol.51 (38), p.8089-8092
Hauptverfasser: Mazid, Romiza R, Vijayaraghavan, R, MacFarlane, Douglas R, Cortez-Jugo, Christina, Cheng, Wenlong
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Antibodies, Monoclonal - chemistry
Antibodies, Monoclonal - metabolism
Buffers
Choline - chemistry
Choline - metabolism
Growth factors
Ionic liquids
Ionic Liquids - chemistry
Ionic Liquids - metabolism
Monoclonal antibodies
Peptide Hydrolases - chemistry
Peptide Hydrolases - metabolism
Receptor, Epidermal Growth Factor - chemistry
Receptor, Epidermal Growth Factor - metabolism
Receptors
Stability
Transportation
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Beschreibung
Zusammenfassung:We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc01877c