The development of a highly photostable and chemically stable zwitterionic near-infrared dye for imaging applications

A novel zwitterionic near-infrared (NIR) dye, ZWCC, has been designed and synthesized. It shows significantly enhanced photostability and chemical stability compared to the existing zwitterionic NIR dye. In addition, the feasibility of labeling ZWCC with biological ligands was investigated and used...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-03, Vol.51 (19), p.3989-3992
Hauptverfasser:	Su, Dongdong, Teoh, Chai Lean, Samanta, Animesh, Kang, Nam-Young, Park, Sung-Jin, Chang, Young-Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival Corrosion resistance Drug Design Drug Stability Dyes Feasibility Fluorescent Dyes - chemistry Humans Imaging Infrared Rays Labels Ligands Marking MCF-7 Cells Molecular Imaging - methods Peptides, Cyclic - chemistry Synthesis
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Beschreibung
Zusammenfassung:	A novel zwitterionic near-infrared (NIR) dye, ZWCC, has been designed and synthesized. It shows significantly enhanced photostability and chemical stability compared to the existing zwitterionic NIR dye. In addition, the feasibility of labeling ZWCC with biological ligands was investigated and used in live cell imaging applications.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c4cc08814j