A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells

A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells

A ratiometric fluorescent probe () for ClO(-) based on the conjugate of coumarin-rhodamine was presented, which could sense ClO(-) with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, is the first mitochondria-targeted ratiometric fluorescent probe to image...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (31), p.6781-6784
Hauptverfasser: Hou, Ji-Ting, Li, Kun, Yang, Jin, Yu, Kang-Kang, Liao, Ye-Xin, Ran, Yu-Zhao, Liu, Yan-Hong, Zhou, Xue-Dong, Yu, Xiao-Qi
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cancer
Cell Line
Conjugates
Coumarins - chemistry
Fluorescence
Fluorescent Dyes - chemistry
Humans
Hypochlorous Acid - chemistry
Hypochlorous Acid - metabolism
Mice
Mitochondria - metabolism
Rhodamines - chemistry
Selectivity
Sensitivity
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Zusammenfassung:A ratiometric fluorescent probe () for ClO(-) based on the conjugate of coumarin-rhodamine was presented, which could sense ClO(-) with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO(-).
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc01217a