Synthesis of 2,2,2,‐Trichloroethyl Aryl‐ and Vinyldiazoacetates by Palladium‐Catalyzed Cross‐Coupling

An efficient and convenient synthesis of 2,2,2‐trichloroethyl (TCE) aryl‐ and vinyldiazoacetates was achieved by palladium‐catalyzed cross‐coupling reactions between TCE diazoacetates and aryl or vinyl iodides. The broad substrate scope allows for rapid and facile formation of TCE aryl‐ and vinyldiazoacetates, which recently have emerged as versatile reagents for rhodium‐carbene chemistry. Making TCE: 2,2,2‐Trichloroethyl (TCE) aryl‐ and vinyldiazoacetates have recently emerged as versatile reagents for rhodium‐carbene chemistry. Herein, an efficient and convenient synthesis of TCE aryl‐ and vinyldiazoacetates by palladium‐catalyzed cross‐coupling reactions between TCE diazoacetates and aryl or vinyl iodides is reported.