Hydrazide macrocycles as effective transmembrane channels for ammonium

Three shape-persistent aromatic hydrazide macrocycles that bear phenylalanine tripeptide chains have been synthesized. These macrocycles can insert into lipid bilayers to form single-molecular ion channels which exhibit a high NH4(+)/K(+) selectivity.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-03, Vol.51 (23), p.4819-4822
Hauptverfasser:	Xin, Pengyang, Zhang, Liang, Su, Pei, Hou, Jun-Li, Li, Zhan-Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Compounds - chemistry Channels Computational Biology Hydrazides Inserts Ion channels Lipids Lipids - chemistry Macrocyclic compounds Macrocyclic Compounds - chemical synthesis Macrocyclic Compounds - chemistry Membranes, Artificial Molecular Structure Phenylalanine Phenylalanine - chemistry Potassium - chemistry Selectivity Synthesis
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Beschreibung
Zusammenfassung:	Three shape-persistent aromatic hydrazide macrocycles that bear phenylalanine tripeptide chains have been synthesized. These macrocycles can insert into lipid bilayers to form single-molecular ion channels which exhibit a high NH4(+)/K(+) selectivity.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc00691k