Synthesis of 1H-indazoles from N-tosylhydrazones and nitroaromatic compounds

A new method for the synthesis of 1H-indazoles from readily available N-tosylhydrazones and nitroaromatic compounds has been developed. This transformation occurs under transition-metal-free conditions and shows a wide substrate scope. The method has been successfully applied to the formal synthesis...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-05, Vol.50 (39), p.5061-5063
Hauptverfasser:	Liu, Zhenxing, Wang, Long, Tan, Haocheng, Zhou, Shiyi, Fu, Tianren, Xia, Ying, Zhang, Yan, Wang, Jianbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Austenitic stainless steels Biocompatibility Biphenyl Compounds - chemistry Catalysis Hydrazones - chemistry Indazoles - chemical synthesis Molecular Structure Nitrobenzenes - chemistry Pyrazoles - chemical synthesis Substrates Synthesis Tosyl Compounds - chemistry Transformations
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Beschreibung
Zusammenfassung:	A new method for the synthesis of 1H-indazoles from readily available N-tosylhydrazones and nitroaromatic compounds has been developed. This transformation occurs under transition-metal-free conditions and shows a wide substrate scope. The method has been successfully applied to the formal synthesis of a bioactive compound, WAY-169916.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c4cc00962b