Sensitive and selective amplified visual detection of cytokines based on exonuclease III-aided target recycling

Sensitive and selective amplified visual detection of cytokines based on exonuclease III-aided target recycling

A new Exo III assisted strand-cleavage cycle and ligand-responsive quadruplex formation strategy for amplified and label-free detection of IFN-γ was reported with a detection limit of 0.1 pM and a visual detection limit of 20 pM by the naked eye.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-11, Vol.50 (87), p.13342-13345
Hauptverfasser: Zhang, Kai, Ren, Tianli, Wang, Ke, Zhu, Xue, Wu, Hao, Xie, Minhao
Format: Artikel
Sprache:eng
Schlagworte:
Amplification
Cytokines
Exodeoxyribonucleases - metabolism
Eyes
Formations
Humans
Interferon-gamma - analysis
Interferon-gamma - metabolism
Ligands
Recycling
Strategy
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Zusammenfassung:A new Exo III assisted strand-cleavage cycle and ligand-responsive quadruplex formation strategy for amplified and label-free detection of IFN-γ was reported with a detection limit of 0.1 pM and a visual detection limit of 20 pM by the naked eye.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05701e