A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (83), p.9588-9590
Hauptverfasser:	Taylor, Paul C, Clark, Andrew J, Marsh, Andrew, Singer, Donald R J, Dilly, Suzanne J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Arrhythmia Agents - metabolism Bacteriophage T7 - genetics Bacteriophages Base Sequence Binding Biocompatibility Controller area network Drosophila - genetics Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism ELISA Enzyme-Linked Immunosorbent Assay Flecainide - metabolism Genes Genomics - methods Molecular Sequence Data Peptide Library Peptides - chemistry Peptides - genetics Peptides - metabolism Protein Biosynthesis Proteins Reading Frames Translations
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