A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (83), p.9588-9590
Hauptverfasser:	Taylor, Paul C, Clark, Andrew J, Marsh, Andrew, Singer, Donald R J, Dilly, Suzanne J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Arrhythmia Agents - metabolism Bacteriophage T7 - genetics Bacteriophages Base Sequence Binding Biocompatibility Controller area network Drosophila - genetics Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism ELISA Enzyme-Linked Immunosorbent Assay Flecainide - metabolism Genes Genomics - methods Molecular Sequence Data Peptide Library Peptides - chemistry Peptides - genetics Peptides - metabolism Protein Biosynthesis Proteins Reading Frames Translations
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Beschreibung
Zusammenfassung:	Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein products of genes linked to sudden cardiac death.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc44647f