A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins
Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (83), p.9588-9590 |
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| container_end_page | 9590 |
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| container_issue | 83 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 49 |
| creator | Taylor, Paul C Clark, Andrew J Marsh, Andrew Singer, Donald R J Dilly, Suzanne J |
| description | Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein products of genes linked to sudden cardiac death. |
| doi_str_mv | 10.1039/c3cc44647f |
| format | Article |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2013-10, Vol.49 (83), p.9588-9590 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1893885706 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Anti-Arrhythmia Agents - metabolism Bacteriophage T7 - genetics Bacteriophages Base Sequence Binding Biocompatibility Controller area network Drosophila - genetics Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism ELISA Enzyme-Linked Immunosorbent Assay Flecainide - metabolism Genes Genomics - methods Molecular Sequence Data Peptide Library Peptides - chemistry Peptides - genetics Peptides - metabolism Protein Biosynthesis Proteins Reading Frames Translations |
| title | A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins |
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