A rapid screen for molecules that form duplex to duplex crosslinks in DNA
We describe a gold nanoparticle based assay that can rapidly determine the crosslinking of DNA duplexes by ligands. Such compounds have potential in targeting highly compacted DNA such as that found in the nucleosome.
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (80), p.9113-9115 |
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| container_end_page | 9115 |
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| container_issue | 80 |
| container_start_page | 9113 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 49 |
| creator | Marín, María J Rackham, Benjamin D Round, Andrew N Howell, Lesley A Russell, David A Searcey, Mark |
| description | We describe a gold nanoparticle based assay that can rapidly determine the crosslinking of DNA duplexes by ligands. Such compounds have potential in targeting highly compacted DNA such as that found in the nucleosome. |
| doi_str_mv | 10.1039/c3cc45600e |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2013-10, Vol.49 (80), p.9113-9115 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1893885695 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Aminacrine - chemistry Assaying Crosslinking Deoxyribonucleic acid DNA - chemistry DNA - metabolism Gold Gold - chemistry Hydrogen-Ion Concentration Ligands Metal Nanoparticles - chemistry Nanostructure Nucleosomes - metabolism Screens Spectrophotometry, Ultraviolet |
| title | A rapid screen for molecules that form duplex to duplex crosslinks in DNA |
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