DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions

DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions

Using the DNA-based catalysis concept, a novel Cu(ii) catalyzed enantioselective oxa-Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were obtained. The presence of water is important for the reactivity, possibly by reverting unwanted side reactions such as 1,2-a...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (51), p.6366-6368
Hauptverfasser: Megens, Rik P, Roelfes, Gerard
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Catalysis
Catalysts
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Zusammenfassung:Using the DNA-based catalysis concept, a novel Cu(ii) catalyzed enantioselective oxa-Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were obtained. The presence of water is important for the reactivity, possibly by reverting unwanted side reactions such as 1,2-additions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc31854g