Photoresponsive quinoline tethered fluorescent carbon dots for regulated anticancer drug delivery

Photoresponsive quinoline tethered fluorescent carbon dots for regulated anticancer drug delivery

A photoresponsive nano drug delivery system (DDS) was constructed using two new ingredients: fluorescent carbon dots and a quinoline based phototrigger. The strong fluorescent properties of carbon dots have been explored for in vitro cellular imaging application, and the phototrigger ability of quin...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-11, Vol.49 (89), p.10471-10473
Hauptverfasser: Karthik, S, Saha, Biswajit, Ghosh, Sudip Kumar, Pradeep Singh, N D
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemistry
Antineoplastic Agents - toxicity
Carbon
Carbon - chemistry
Cell Survival - drug effects
Chlorambucil - chemistry
Chlorambucil - toxicity
Drug Carriers - chemistry
Drug delivery systems
Fluorescence
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Imaging
Ingredients
Microscopy, Confocal
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Photolysis
Quinoline
Quinolines - chemistry
Quinolines - toxicity
Ultraviolet Rays
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Zusammenfassung:A photoresponsive nano drug delivery system (DDS) was constructed using two new ingredients: fluorescent carbon dots and a quinoline based phototrigger. The strong fluorescent properties of carbon dots have been explored for in vitro cellular imaging application, and the phototrigger ability of quinoline was exploited for efficient anticancer drug release using both one-photon and two-photon excitation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46078a