Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles

Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles

Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C-H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-11, Vol.50 (91), p.14249-14252
Hauptverfasser: Kim, Minyoung, Mishra, Neeraj Kumar, Park, Jihye, Han, Sangil, Shin, Youngmi, Sharma, Satyasheel, Lee, Youngil, Lee, Eui-Kyung, Kwak, Jong Hwan, Kim, In Su
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Acylation
Catalysis
Chemical bonds
Decarboxylation
Heterocyclic aromatic compounds
Indoles
Indoles - chemical synthesis
Indoles - chemistry
Keto Acids - chemistry
Molecular Structure
Palladium
Palladium - chemistry
Strategy
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Zusammenfassung:Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C-H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06929c