Highly regioselective and chemoselective titanocene mediated Barbier-type allylation reactions

Highly regioselective and chemoselective titanocene mediated Barbier-type allylation reactions

Titanocene carboxylate 1 is an excellent chemoselective reagent for unprecedented α-regioselective Barbier-type reactions. It constitutes the first titanocene(III) able to tolerate epoxides and readily reduced carbonyl compounds, such as aromatic and α,β-unsaturated aldehydes.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (17), p.2211-2213
Hauptverfasser: Morcillo, Sara P, Martínez-Peragón, Ángela, Jakoby, Verena, Mota, Antonio J, Kube, Christian, Justicia, José, Cuerva, Juan M, Gansäuer, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Allyl compounds
Aromatic compounds
Carbonyl compounds
Carboxylates
Chemical reactions
Reagents
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Zusammenfassung:Titanocene carboxylate 1 is an excellent chemoselective reagent for unprecedented α-regioselective Barbier-type reactions. It constitutes the first titanocene(III) able to tolerate epoxides and readily reduced carbonyl compounds, such as aromatic and α,β-unsaturated aldehydes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc49230c