Organelle-selective fluorescent Cu super(2+) ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Organelle-selective fluorescent Cu super(2+) ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Two novel Cu super(2+) sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu super(2+) sensing. The ER-selective Cu super(2+) sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartm...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-02, Vol.50 (24), p.3197-3200
Hauptverfasser: Lee, Yun Hak, Park, Nayoung, Park, Young Bin, Hwang, Yu Jeong, Kang, Chulhun, Kim, Jong Seung
Format: Artikel
Sprache:eng
Schlagworte:
Copper
Endoplasmic reticulum
Fluorescence
Ion probes
Organelles
Reservoirs
Sensors
Synthesis
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Zusammenfassung:Two novel Cu super(2+) sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu super(2+) sensing. The ER-selective Cu super(2+) sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc00091a