Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis

Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis

We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including α-imidaz...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (15), p.1867-1870
Hauptverfasser: Alzieu, Thibaut, Lehmann, Johannes, Naidu, Ajay B, Martin, Rainer E, Britton, Robert
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry Techniques, Synthetic
Converting
Direct conversion
Esters
Imidazole
Imidazoles - chemical synthesis
Imidazoles - chemistry
Microwaves
Optimization
Oxazole
Oxazoles - chemistry
Synthesis
Utilities
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Beschreibung
Zusammenfassung:We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including α-imidazolyl esters.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc48467j