Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using s...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-11, Vol.50 (87), p.13388-13390
Hauptverfasser: Jeong, Eun Hye, Ryu, Ji Hyun, Jeong, Hansaem, Jang, Bora, Lee, Ho Yeon, Hong, Seonki, Lee, Haeshin, Lee, Hyukjin
Format: Artikel
Sprache:eng
Schlagworte:
Cytoplasm
Cytoplasm - genetics
Cytoplasm - metabolism
Flavonoids
Flavonoids - chemistry
Flavonoids - metabolism
Gene expression
Gene Silencing
Gene Transfer Techniques
Genes
Gold
Gold - chemistry
Gold - metabolism
HeLa Cells
Humans
Metal Nanoparticles - chemistry
Nanostructure
Particle Size
Photochemical Processes
RNA, Small Interfering - genetics
RNA, Small Interfering - metabolism
Surface Properties
Temperature
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Zusammenfassung:Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc07155g