Type III-B rotaxane dendrimers

Type III-B rotaxane dendrimers

Type III-B first generation [3]rotaxane and second generation [4]rotaxane dendrimers have been synthesized via (1) a modified copper-catalyzed alkyne-azide cycloaddition (CuAAC), (2) Glaser-Hay's acetylenic oxidative homo-coupling, and (3) amide formation. The dendron does not reveal obvious cy...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-11, Vol.49 (92), p.10781-10783
Hauptverfasser: Ho, Watson K-W, Lee, Siu-Fung, Wong, Chi-Hin, Zhu, Xiao-Ming, Kwan, Chak-Shing, Chak, Chun-Pong, Mendes, Paula M, Cheng, Christopher H K, Leung, Ken Cham-Fai
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Amides
Ammonia
Animals
Cell Line
Cell Survival
Cyclization
Dendrimers
Dendrimers - chemical synthesis
Dendrimers - chemistry
Fibroblasts
Fibroblasts - cytology
Mice
Molecular Structure
Rotaxanes
Rotaxanes - chemical synthesis
Rotaxanes - chemistry
Synthesis
Toxicity
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Zusammenfassung:Type III-B first generation [3]rotaxane and second generation [4]rotaxane dendrimers have been synthesized via (1) a modified copper-catalyzed alkyne-azide cycloaddition (CuAAC), (2) Glaser-Hay's acetylenic oxidative homo-coupling, and (3) amide formation. The dendron does not reveal obvious cytotoxicities in L929 fibroblast cells. The rotaxane dendrimers can capture ammonia and are switchable both in solution and on surfaces.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46759g