Metal-free O-H/C-H difunctionalization of phenols by o -hydroxyarylsulfonium salts in water

Metal-free O-H/C-H difunctionalization of phenols by o -hydroxyarylsulfonium salts in water

An environmentally benign method for C-H/O-H difunctionalization of phenols with sulfoxides under mild conditions has been developed. The reaction process is mediated by an electrophilic aromatic substitution and subsequent selective aryl or alkyl migration, involving C-S and C-O bond formations wit...

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Veröffentlicht in:Chemical science (Cambridge) 2017, Vol.8 (2), p.1601-1606
Hauptverfasser: Chen, Dengfeng, Feng, Qingyuan, Yang, Yunqin, Cai, Xu-Min, Wang, Fei, Huang, Shenlin
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Bonding
Migration
Phenols
Substrates
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Zusammenfassung:An environmentally benign method for C-H/O-H difunctionalization of phenols with sulfoxides under mild conditions has been developed. The reaction process is mediated by an electrophilic aromatic substitution and subsequent selective aryl or alkyl migration, involving C-S and C-O bond formations with broad substrate scope.
ISSN:2041-6520
2041-6539
DOI:10.1039/c6sc04504a