Atorvastatin as a promising anticryptococcal agent

Highlights • Drug repositioning is a fast and cheap strategy for the establishment of new antifungals. • Atorvastatin combined with fluconazole improved cryptococcosis caused by Cryptococcus gattii. • The polysaccharide capsule and fungal cell membrane are changed in the presence of statin. • These...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-06, Vol.49 (6), p.695-702
Hauptverfasser:	Ribeiro, Noelly de Queiroz, Costa, Marliete Carvalho, Magalhães, Thaís Furtado Ferreira, Carneiro, Hellem Cristina Silva, Oliveira, Lorena Vívien, Fontes, Alide Caroline Lima, Santos, Julliana Ribeiro Alves, Ferreira, Gabriela Freitas, Araujo, Glauber Ribeiro de Sousa, Alves, Vinícius, Frases, Susana, Paixão, Tatiane Alves, de Resende Stoianoff, Maria Aparecida, Santos, Daniel Assis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Atorvastatin Atorvastatin Calcium - pharmacology Atorvastatin Calcium - therapeutic use Cryptococcosis - drug therapy Cryptococcosis - microbiology Cryptococcus gattii Cryptococcus gattii - drug effects Disease Models, Animal Drug Repositioning Drug Therapy, Combination - methods Fluconazole - pharmacology Fluconazole - therapeutic use Infectious Disease Male Mice, Inbred C57BL Survival Analysis Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • Drug repositioning is a fast and cheap strategy for the establishment of new antifungals. • Atorvastatin combined with fluconazole improved cryptococcosis caused by Cryptococcus gattii. • The polysaccharide capsule and fungal cell membrane are changed in the presence of statin. • These modifications induce death of C. gattii within phagocytes. • Mice treated with atorvastatin had increased survival and better clinical outcome.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2017.04.005