Impact of primary platinum-free interval and BRCA1/2 mutation status on treatment and survival in patients with recurrent ovarian cancer

Highlights • Primary platinum-free interval correlates with PFS and OS across multiple therapies. • BRCA testing averaged 36% in this community-based sample. • Presence of a BRCA mutation trends toward delayed primary recurrence. • Data provide benchmarks for design and interpretation of trials in r...

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Veröffentlicht in:	Gynecologic oncology 2017-07, Vol.146 (1), p.58-63
Hauptverfasser:	Bookman, Michael A, Tyczynski, Jerzy E, Espirito, Janet L, Wilson, Thomas W, Fernandes, Ancilla W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - administration & dosage BRCA1/2 Carcinoma, Ovarian Epithelial Female Genes, BRCA1 Genes, BRCA2 Germ-Line Mutation Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Middle Aged Neoplasm Grading Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - therapy Neoplasm Staging Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - mortality Obstetrics and Gynecology Organoplatinum Compounds - administration & dosage Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality PARP Platinum-free interval Retrospective Studies United States - epidemiology Young Adult
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Zusammenfassung:	Highlights • Primary platinum-free interval correlates with PFS and OS across multiple therapies. • BRCA testing averaged 36% in this community-based sample. • Presence of a BRCA mutation trends toward delayed primary recurrence. • Data provide benchmarks for design and interpretation of trials in recurrent disease.
ISSN:	0090-8258 1095-6859
DOI:	10.1016/j.ygyno.2017.04.011