Frameless stereotactic radiosurgery for the treatment of multiple sclerosis-related trigeminal neuralgia

Abstract Background Trigeminal neuralgia (TN) affects 7% of patients with multiple sclerosis (MS). In such patients, TN is difficult to manage either pharmacologically and surgically. Radiosurgical rhizotomy is an effective treatment option. The non-isocentric geometry of radiation beams of CyberKni...

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Veröffentlicht in:	World neurosurgery 2017-07, Vol.103, p.702-712
Hauptverfasser:	Conti, Alfredo, MD, PhD, Pontoriero, Antonio, MD, Iatì, Giuseppe, MD, Esposito, Felice, MD, PhD, Siniscalchi, Enrico Nastro, MD, DO, Crimi, Salvatore, MD, Vinci, Sergio, MD, Brogna, Anna, PhD, Ponte, Francesco De, MD, Germanò, Antonino, MD, Pergolizzi, Stefano, MD, Tomasello, Francesco, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	CyberKnife Facial numbness Female Follow-Up Studies Frameless radiosurgery Humans Magnetic Resonance Imaging Male Middle Aged Multiple sclerosis Multiple Sclerosis - complications Neurosurgery Radiosurgery - methods Radiotherapy, Image-Guided Rhizotomy - methods Stereotactic radiosurgery Tomography, X-Ray Computed Trigeminal Nerve - diagnostic imaging Trigeminal neuralgia Trigeminal Neuralgia - etiology Trigeminal Neuralgia - radiotherapy
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Zusammenfassung:	Abstract Background Trigeminal neuralgia (TN) affects 7% of patients with multiple sclerosis (MS). In such patients, TN is difficult to manage either pharmacologically and surgically. Radiosurgical rhizotomy is an effective treatment option. The non-isocentric geometry of radiation beams of CyberKnife introduces new concepts in the treatment of TN. Its efficacy for MS-related TN has not yet been demonstrated. Methods Twenty-seven patients with refractory TN and MS were treated. A non-isocentric beams distribution was chosen; the maximal target dose was 72.5 Gy. The maximal dose to the brainstem was
ISSN:	1878-8750 1878-8769
DOI:	10.1016/j.wneu.2017.04.102