Calcium Dependence of the Interaction between Calmodulin and Anthrax Edema Factor

Edema factor (EF), a toxin from Bacillus anthracis (anthrax), possesses adenylyl cyclase activity and requires the ubiquitous Ca2+-sensor calmodulin (CaM) for activity. CaM can exist in three major structural states: an apo state with no Ca2+ bound, a two Ca2+ state with its C-terminal domain Ca2+-l...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (31), p.29261-29266
Hauptverfasser:	Ulmer, Tobias S., Soelaiman, Sandriyana, Li, Shipeng, Klee, Claude B., Tang, Wei-Jen, Bax, Ad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Antigens, Bacterial Apoproteins - chemistry Apoproteins - metabolism Bacillus anthracis Bacillus anthracis - chemistry Bacterial Toxins Calcium - metabolism Calcium - pharmacology Calmodulin - chemistry Calmodulin - metabolism Drug Interactions Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Peptide Fragments - metabolism
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