Polypropylene mesh seeded with fibroblasts: A new approach for the repair of abdominal wall defects in rats

Highlights • Developed bioengineered scaffolds by seeding primary mouse embryo fibroblast cells (p-MEF) on polypropylene mesh. • Successfully tested the efficacy of the bio-engineered matrices in the reconstruction of full thickness abdominal wall defects in rats. • In vitro seeding of mesh with fibroblasts resulted in earlier subsidization of pain, angiogenesis and deposition of collagen, increased thickness of matrices with lesser adhesions with underlying viscera.