Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions

Highlights • The majority of CD163+ and CD8+ cells are found in the superficial lamina propria. • Increase in CD163+ cell number represents a risk factor for high-grade dysplasia. • Subepithelial PD-L1+ cell number is associated with malignant transformation risk. • Epithelial PD-L1 positivity is as...

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Veröffentlicht in:	Oral oncology 2017-05, Vol.68, p.36-43
Hauptverfasser:	Yagyuu, Takahiro, Hatakeyama, Kinta, Imada, Mitsuhiko, Kurihara, Miyako, Matsusue, Yumiko, Yamamoto, Kazuhiko, Obayashi, Chiho, Kirita, Tadaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antigens, CD - immunology B7-H1 Antigen - metabolism CD163 Child Female Hematology, Oncology and Palliative Medicine Humans Immunophenotyping Macrophage Male Middle Aged Mouth Neoplasms - immunology Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Oral cancer Oral leukoplakia Otolaryngology Precancerous Conditions - immunology Precancerous Conditions - metabolism Precancerous Conditions - pathology Programmed cell death 1-ligand 1 Retrospective Studies Survival Analysis Tumor Microenvironment Tumor-infiltrating lymphocyte Young Adult
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Zusammenfassung:	Highlights • The majority of CD163+ and CD8+ cells are found in the superficial lamina propria. • Increase in CD163+ cell number represents a risk factor for high-grade dysplasia. • Subepithelial PD-L1+ cell number is associated with malignant transformation risk. • Epithelial PD-L1 positivity is associated with malignant transformation risk. • PD-L1 inhibition may prevent malignant transformation of oral precancerous legions.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2017.03.006