The association of urinary interferon-gamma inducible protein-10 (IP10/CXCL10) levels with kidney allograft rejection

The association of urinary interferon-gamma inducible protein-10 (IP10/CXCL10) levels with kidney allograft rejection

Background Interferon-gamma inducible protein-10 (IP-10/CXCL10) is a chemokine involved in the alloimmune response against kidney allograft. We aimed to investigate the association of urinary CXCL10 protein levels with rejection in renal transplant patients. Methods A total of 273 urine samples from...

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Veröffentlicht in:Inflammation research 2017-05, Vol.66 (5), p.425-432
Hauptverfasser: Raza, Ali, Firasat, Sadaf, Khaliq, Shagufta, Aziz, Tahir, Mubarak, Muhammed, Naqvi, Syed Ali Anwar, Mehdi, Syed Qasim, Rizvi, Syed Adib-ul-Hasan, Abid, Aiysha
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Allergology
Biomedical and Life Sciences
Biomedicine
Chemokine CXCL10 - urine
Dermatology
Female
Graft Rejection - urine
Humans
Immunology
Kidney Transplantation
Male
Middle Aged
Neurology
Original Research Paper
Pharmacology/Toxicology
Rheumatology
Young Adult
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Zusammenfassung:Background Interferon-gamma inducible protein-10 (IP-10/CXCL10) is a chemokine involved in the alloimmune response against kidney allograft. We aimed to investigate the association of urinary CXCL10 protein levels with rejection in renal transplant patients. Methods A total of 273 urine samples from (biopsy-proven) rejection and non-rejection patients and controls were included in this study. CXCL10 levels were analyzed for association with rejection. Results The data showed statistically significant differences in the CXCL10 levels between rejection vs. non-rejection ( p  
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-017-1025-7