Lung function not affected by asbestos exposure in workers with normal Computed Tomography scan

Background: It has been suggested that asbestos exposure affects lung function, even in the absence of asbestos‐related pulmonary interstitial or pleural changes or emphysema. Methods: We analyzed associations between well‐known asbestos‐related risk factors, such as individual cumulative asbestos e...

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Veröffentlicht in:American journal of industrial medicine 2017-05, Vol.60 (5), p.422-431
Hauptverfasser: Schikowsky, Christian, Felten, Michael K., Eisenhawer, Christian, Das, Marco, Kraus, Thomas
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Sprache:eng
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Zusammenfassung:Background: It has been suggested that asbestos exposure affects lung function, even in the absence of asbestos‐related pulmonary interstitial or pleural changes or emphysema. Methods: We analyzed associations between well‐known asbestos‐related risk factors, such as individual cumulative asbestos exposure, and key lung function parameters in formerly asbestos‐exposed power industry workers (N = 207) with normal CT scans. For this, we excluded participants with emphysema, fibrosis, pleural changes, or any combination of these. Results: The lung function parameters of FVC, FEV1, DLCO/VA, and airway resistance were significantly associated with the burden of smoking, BMI and years since end of exposure (only DLCO/VA). However, they were not affected by factors directly related to amount (eg, cumulative exposure) or duration of asbestos exposure. Conclusions: Our results confirm the well‐known correlation between lung function, smoking habits, and BMI. However, we found no significant association between lung function and asbestos exposure.
ISSN:0271-3586
1097-0274
DOI:10.1002/ajim.22717