Exercise-modulated epigenetic markers and inflammatory response in COPD individuals: a pilot study

Exercise-modulated epigenetic markers and inflammatory response in COPD individuals: a pilot study

Highlights • A DNA hypomethylation status was found after the 1st PRP session in COPD patients. • No significant changes were observed on cytokine levels after the 1st PRP session. • The PRP did not alter global histone H4 acetylation levels in COPD patients. • 24 sessions of PRP reduced IL-6 and IL...

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Veröffentlicht in:Respiratory physiology & neurobiology 2017-08, Vol.242, p.89-95
Hauptverfasser: da Silva, Ivy Reichert Vital, de Araujo, Cintia Laura Pereira, Dorneles, Gilson Pires, Peres, Alessandra, Bard, Andreia Luciana, Reinaldo, Gustavo, Teixeira, Paulo José Zimermann, Lago, Pedro Dal, Elsner, Viviane Rostirola
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
Aged
Biomarkers - blood
COPD
Cytokines - blood
DNA Methylation
Dyspnea - blood
Dyspnea - genetics
Dyspnea - immunology
Dyspnea - rehabilitation
Epigenesis, Genetic
Exercise
Exercise - physiology
Exercise Therapy
Female
Global DNA methylation
Global histone H4 acetylation
Histones - blood
Humans
Inflammatory response
Male
Medical Education
Pilot Projects
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - genetics
Pulmonary Disease, Chronic Obstructive - immunology
Pulmonary Disease, Chronic Obstructive - rehabilitation
Pulmonary/Respiratory
Quality of Life
Sedentary Lifestyle
Treatment Outcome
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Zusammenfassung:Highlights • A DNA hypomethylation status was found after the 1st PRP session in COPD patients. • No significant changes were observed on cytokine levels after the 1st PRP session. • The PRP did not alter global histone H4 acetylation levels in COPD patients. • 24 sessions of PRP reduced IL-6 and IL-8 levels in COPD patients. • Epigenetic machinery may mediates the anti-inflammatory effects of PRP.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2017.04.004