Repurposing QuantiFERON for Detection of Neutralizing Interferon-γ Autoantibodies in Patients With Nontuberculous Mycobacterial Infections

Nontuberculous mycobacterial infections due to autoantibodies targeting interferon-γ are an emerging medical problem. However, case finding is hampered due to highly complex diagnostic procedures not available in routine laboratories. We show that QuantiFERON assays can be exploited as a simple scre...

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Veröffentlicht in:	Clinical infectious diseases 2017-08, Vol.65 (3), p.518-521
Hauptverfasser:	Suárez, Isabelle, Lehmann, Clara, Gruell, Henning, Graeb, Jessica, Kochanek, Matthias, Fätkenheuer, Gerd, Plum, Georg, van Wengen, Annelies, van de Vosse, Esther, Hartmann, Pia, Hanitsch, Leif G., Rybniker, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Autoantibodies Autoantibodies - blood Autoantibodies - immunology Bacterial infections BRIEF REPORT Diagnostic systems Female Humans Infections Interferon Interferon-gamma - immunology Interferon-gamma Release Tests - methods Medical screening Medical treatment Middle Aged Mycobacterium Infections, Nontuberculous - diagnosis Mycobacterium Infections, Nontuberculous - immunology Nontuberculous Mycobacteria γ-Interferon
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Zusammenfassung:	Nontuberculous mycobacterial infections due to autoantibodies targeting interferon-γ are an emerging medical problem. However, case finding is hampered due to highly complex diagnostic procedures not available in routine laboratories. We show that QuantiFERON assays can be exploited as a simple screening tool that may facilitate adequate and timely treatment.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cix372