Effect of Anti-Norepinephrine Antibodies on the Development of Neuropathic Pain

The study focuses on induction of autoantibodies directed against neurotransmitter norepinephrine during neuropathic pain syndrome and on the effect of immunization with norepinephrine-protein conjugated antigen on the development of this syndrome. The formation of anti-norepinephrine antibodies agg...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2017-04, Vol.162 (6), p.714-717
Hauptverfasser:	Igon’kina, S. I., Vetrile, L. A., Kukushkin, M. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Autoantibodies Autoantibodies - biosynthesis Autoantibodies - blood Autoimmunity Biomedical and Life Sciences Biomedicine Catecholamines Cell Biology Femoral Nerve - injuries Femoral Nerve - physiopathology Freund's Adjuvant - administration & dosage General Pathology and Pathophysiology Immunization Immunoconjugates - administration & dosage Injections, Subcutaneous Internal Medicine Laboratory Medicine Male Neuralgia Neuralgia - etiology Neuralgia - immunology Neuralgia - physiopathology Norepinephrine Norepinephrine - administration & dosage Norepinephrine - chemistry Norepinephrine - immunology Pain Pain management Pathology Peripheral Nerve Injuries - complications Peripheral Nerve Injuries - immunology Peripheral Nerve Injuries - pathology Peripheral Nerve Injuries - physiopathology Rats Rats, Wistar Sciatic Nerve - injuries Sciatic Nerve - physiopathology Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - immunology Severity of Illness Index
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Beschreibung
Zusammenfassung:	The study focuses on induction of autoantibodies directed against neurotransmitter norepinephrine during neuropathic pain syndrome and on the effect of immunization with norepinephrine-protein conjugated antigen on the development of this syndrome. The formation of anti-norepinephrine antibodies aggravated and prolonged neuropathic pain.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-017-3695-0