Magnetic Resonance Imaging of Tumors with the Use of Iron Oxide Magnetic Nanoparticles as a Contrast Agent

We studied the possibility of using BSA-coated magnetic iron oxide nanoparticles for magnetic resonance imaging diagnosis of C6 glioblastoma, 4T1 mammary adenocarcinoma, and RS-1 hepatic mucous carcinoma. In all three cases, magnetic nanoparticles accumulated in the tumor and its large vessels. Magn...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2017-04, Vol.162 (6), p.808-811
Hauptverfasser:	Semkina, A. S., Abakumov, M. A., Grinenko, N. F., Lipengolts, A. A., Nukolova, N. V., Chekhonin, V. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - diagnostic imaging Adenocarcinoma - metabolism Adenocarcinoma, Mucinous - diagnostic imaging Adenocarcinoma, Mucinous - metabolism Animals Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - metabolism Cancer Cell Biology Cell Line, Tumor Contrast agents Contrast media Contrast Media - chemistry Contrast Media - pharmacokinetics Female Ferric Compounds - administration & dosage Ferric Compounds - chemistry Ferric oxide Glioblastoma Glioma - diagnostic imaging Glioma - metabolism Gliomas Injections, Subcutaneous Internal Medicine Iron Iron compounds Laboratory Medicine Liver Neoplasms - diagnostic imaging Liver Neoplasms - metabolism Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - administration & dosage Mammary Neoplasms, Experimental - diagnostic imaging Mammary Neoplasms, Experimental - metabolism Mice Mice, Inbred BALB C Nanoparticles NMR Nuclear magnetic resonance Pathology Prognosis Rats Rats, Wistar Tumors Vascularization
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Zusammenfassung:	We studied the possibility of using BSA-coated magnetic iron oxide nanoparticles for magnetic resonance imaging diagnosis of C6 glioblastoma, 4T1 mammary adenocarcinoma, and RS-1 hepatic mucous carcinoma. In all three cases, magnetic nanoparticles accumulated in the tumor and its large vessels. Magnetic resonance imaging with contrast agent allows visualization of the tumor tissue and its vascularization.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-017-3718-x