Ticagrelor Versus Clopidogrel on Myocardial Infarct Size in Patients Undergoing Primary Percutaneous Coronary Intervention

[...]sample size calculation was based on rational background, infarct size was assessed blindly, and results of subgroup analysis were consistent. [...]we demonstrated that ticagrelor reduced myocardial infarct size and microvascular obstruction in patients with STEMI. Ticagrelor (n = 45) Clopidogrel (n = 50) p Value Infarct size, % LV 21.5 ± 10.9 26.5 ± 11.3 0.03 Microvascular obstruction, % LV 3.0 (0-9.2) 5.3 (0.5-10.9) 0.02 Mean transmurality score 1.9 ± 0.5 2.1 ± 0.4 0.06 LV ejection fraction, % 55.2 ± 9.5 52.8 ± 8.7 0.21 Final TIMI flow grade 3 43 (95.6) 44 (88.0) 0.19 Myocardial blush grade 2/3 39 (86.6) 37 (74.0) 0.89 Complete ST-segment elevation resolution 21 (46.7) 24 (48.0) 0.90 Peak CK-MB fraction, ng/mL 170.4 (80.5-267.4) 232.7 (117.1-310.2) 0.04 P2Y12 reaction unit 216.1 ± 83.6 231.0 ± 64.0 0.34 References 1 L. Wallentin, R.C. Becker, A. Budaj, Ticagrelor versus clopidogrel in patients with acute coronary syndromes,...