The detection of antigenic determinants of Acinetobacter baumannii

Highlights • Acinetobacter baumannii emerged as a major illness and mortality cause in ICUs. • Resistance and ineffective control highlighted early diagnosis and prevention. • Mimicking the infection proved success to highlight effective epitopes. • LPS is a main pillar in producing a diagnostic too...

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Veröffentlicht in:	Immunology letters 2017-06, Vol.186, p.59-67
Hauptverfasser:	Tawfik, Dina M, Ahmad, Tarek A, Sheweita, Salah A, Haroun, Medhat, El-Sayed, Laila H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii Acinetobacter baumannii - immunology Acinetobacter Infections - immunology Allergy and Immunology Animals Antigens, Bacterial - immunology Antigens, Bacterial - metabolism Bacterial Vaccines - immunology Cell Proliferation Cells, Cultured Critical Care Cross Infection - immunology Epitope Mapping Epitopes - immunology Epitopes - metabolism Humans Immunity, Humoral Immunization Immunoglobulin G - blood Lipopolysaccharide Mice Mice, Inbred C57BL Orotidine-5'-Phosphate Decarboxylase - immunology Orotidine-5'-Phosphate Decarboxylase - metabolism Outer membrane protein Vaccines
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Beschreibung
Zusammenfassung:	Highlights • Acinetobacter baumannii emerged as a major illness and mortality cause in ICUs. • Resistance and ineffective control highlighted early diagnosis and prevention. • Mimicking the infection proved success to highlight effective epitopes. • LPS is a main pillar in producing a diagnostic tool against the bacterium. • Whilst the potent vaccine should consist of combined pure OMPs and detoxified LPS.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2017.04.004