Predominance of international clone 2 OXA-23-producing- Acinetobacter baumannii clinical isolates in Greece, 2015: results of a nationwide study

Predominance of international clone 2 OXA-23-producing- Acinetobacter baumannii clinical isolates in Greece, 2015: results of a nationwide study

Highlights • Greece has the highest rate of carbapenem-resistant A. baumannii (CRAB) in Europe. • Of the 194 CRAB isolates tested, the vast majority (98.5%) produced OXA-23 carbapenemase. • Colistin showed an alarming resistance rate (27.3%) followed by minocycline (28.4%). • Cotrimoxazole exhibited...

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Veröffentlicht in:International journal of antimicrobial agents 2017-06, Vol.49 (6), p.749-753
Hauptverfasser: Pournaras, Spyros, Dafopoulou, Konstantina, Del Franco, Mariateresa, Zarkotou, Olympia, Dimitroulia, Evangelia, Protonotariou, Efi, Poulou, Aggeliki, Zarrilli, Raffaele, Tsakris, Athanasios
Format: Artikel
Sprache:eng
Schlagworte:
Acinetobacter baumannii - classification
Acinetobacter baumannii - enzymology
Acinetobacter baumannii - isolation & purification
Acinetobacter Infections - epidemiology
Acinetobacter Infections - microbiology
Anti-Bacterial Agents - pharmacology
beta-Lactamases - genetics
beta-Lactamases - secretion
Clonal complex
Electrophoresis, Gel, Pulsed-Field
Female
Genotype
Greece - epidemiology
Humans
Infectious Disease
Male
Microbial Sensitivity Tests
Molecular Epidemiology
Multilocus Sequence Typing
Oxacillinase
Polymerase Chain Reaction
Single-locus blaOXA-51-like sequence-based typing
Tertiary Care Centers
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Zusammenfassung:Highlights • Greece has the highest rate of carbapenem-resistant A. baumannii (CRAB) in Europe. • Of the 194 CRAB isolates tested, the vast majority (98.5%) produced OXA-23 carbapenemase. • Colistin showed an alarming resistance rate (27.3%) followed by minocycline (28.4%). • Cotrimoxazole exhibited susceptibility rates of 34.6%. • Of 194 isolates throughout Greece, IC2 comprised 80.9% and IC1 18.6%.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2017.01.028