Four New Diterpene Glucosides from Perovskia atriplicifolia
Four new diterpene glucosides, namely perovskiaditerpenosides A – D (1 – 4), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated c...
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| Veröffentlicht in: | Chemistry & biodiversity 2017-07, Vol.14 (7), p.n/a |
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| container_title | Chemistry & biodiversity |
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| creator | Gao, Lu Zhou, Jun Zhu, Le‐Yu Zhang, Juan‐Rong Jing, Yu‐Xing Zhao, Jia‐Wen Huang, Xiang‐Zhong Li, Gan‐Peng Jiang, Zhi‐Yong Xue, Da‐Yuan |
| description | Four new diterpene glucosides, namely perovskiaditerpenosides A – D (1 – 4), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity. |
| doi_str_mv | 10.1002/cbdv.201700071 |
| format | Article |
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Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.201700071</identifier><identifier>PMID: 28419767</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Butanols ; Cell Line, Tumor ; Cytotoxic activities ; Cytotoxicity ; Diterpene glucosides ; Diterpenes - isolation & purification ; Drug Screening Assays, Antitumor ; Glucosides ; Glucosides - isolation & purification ; Humans ; Infrared spectroscopy ; Labiatae ; Lamiaceae - chemistry ; Molecular Structure ; NMR ; Nuclear magnetic resonance ; Perovskia atriplicifolia ; Perovskiaditerpenosides A – D ; Plant Extracts ; Spectroscopic analysis ; Spectrum Analysis</subject><ispartof>Chemistry & biodiversity, 2017-07, Vol.14 (7), p.n/a</ispartof><rights>2017 Wiley‐VHCA AG, Zurich, Switzerland</rights><rights>2017 Wiley-VHCA AG, Zurich, Switzerland.</rights><rights>2017 Wiley-VHCA AG, Zurich, Switzerland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4391-a59b7134e73d6fdefdf46615c1753386c362102de46b41e82322d36b1c8afcea3</citedby><cites>FETCH-LOGICAL-c4391-a59b7134e73d6fdefdf46615c1753386c362102de46b41e82322d36b1c8afcea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.201700071$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.201700071$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28419767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Lu</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Zhu, Le‐Yu</creatorcontrib><creatorcontrib>Zhang, Juan‐Rong</creatorcontrib><creatorcontrib>Jing, Yu‐Xing</creatorcontrib><creatorcontrib>Zhao, Jia‐Wen</creatorcontrib><creatorcontrib>Huang, Xiang‐Zhong</creatorcontrib><creatorcontrib>Li, Gan‐Peng</creatorcontrib><creatorcontrib>Jiang, Zhi‐Yong</creatorcontrib><creatorcontrib>Xue, Da‐Yuan</creatorcontrib><title>Four New Diterpene Glucosides from Perovskia atriplicifolia</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>Four new diterpene glucosides, namely perovskiaditerpenosides A – D (1 – 4), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Butanols</subject><subject>Cell Line, Tumor</subject><subject>Cytotoxic activities</subject><subject>Cytotoxicity</subject><subject>Diterpene glucosides</subject><subject>Diterpenes - isolation & purification</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Glucosides</subject><subject>Glucosides - isolation & purification</subject><subject>Humans</subject><subject>Infrared spectroscopy</subject><subject>Labiatae</subject><subject>Lamiaceae - chemistry</subject><subject>Molecular Structure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Perovskia atriplicifolia</subject><subject>Perovskiaditerpenosides A – D</subject><subject>Plant Extracts</subject><subject>Spectroscopic analysis</subject><subject>Spectrum Analysis</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPwzAQRi0EolBYGVEkFpYWn53YiZigpQWpAgZgtRznIrmkTbCbVv33uGopEgvTnU7vPt09Qi6A9oFSdmPyYtlnFCSlVMIBOQEBrAdpSg_3vWQdcur9NPBhnh6TDktjyKSQJ-R2VLcuesZVNLQLdA3OMRpXram9LdBHpatn0Su6euk_rY70wtmmssaWdWX1GTkqdeXxfFe75H308DZ47E1exk-Du0nPxDyDnk6yXAKPUfJClAWWRRkLAYkBmXCeCsMFA8oKjEUeA6aMM1ZwkYNJdWlQ8y653uY2rv5q0S_UzHqDVaXnWLdehW8zmTIpaECv_qDT8N88XKcgA5ElHCAOVH9LGVd777BUjbMz7dYKqNpoVRutaq81LFzuYtt8hsUe__EYgGwLrGyF63_i1OB--PEb_g1smYJy</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Gao, Lu</creator><creator>Zhou, Jun</creator><creator>Zhu, Le‐Yu</creator><creator>Zhang, Juan‐Rong</creator><creator>Jing, Yu‐Xing</creator><creator>Zhao, Jia‐Wen</creator><creator>Huang, Xiang‐Zhong</creator><creator>Li, Gan‐Peng</creator><creator>Jiang, Zhi‐Yong</creator><creator>Xue, Da‐Yuan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Four New Diterpene Glucosides from Perovskia atriplicifolia</title><author>Gao, Lu ; Zhou, Jun ; Zhu, Le‐Yu ; Zhang, Juan‐Rong ; Jing, Yu‐Xing ; Zhao, Jia‐Wen ; Huang, Xiang‐Zhong ; Li, Gan‐Peng ; Jiang, Zhi‐Yong ; Xue, Da‐Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4391-a59b7134e73d6fdefdf46615c1753386c362102de46b41e82322d36b1c8afcea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Butanols</topic><topic>Cell Line, Tumor</topic><topic>Cytotoxic activities</topic><topic>Cytotoxicity</topic><topic>Diterpene glucosides</topic><topic>Diterpenes - isolation & purification</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Glucosides</topic><topic>Glucosides - isolation & purification</topic><topic>Humans</topic><topic>Infrared spectroscopy</topic><topic>Labiatae</topic><topic>Lamiaceae - chemistry</topic><topic>Molecular Structure</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Perovskia atriplicifolia</topic><topic>Perovskiaditerpenosides A – D</topic><topic>Plant Extracts</topic><topic>Spectroscopic analysis</topic><topic>Spectrum Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Lu</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Zhu, Le‐Yu</creatorcontrib><creatorcontrib>Zhang, Juan‐Rong</creatorcontrib><creatorcontrib>Jing, Yu‐Xing</creatorcontrib><creatorcontrib>Zhao, Jia‐Wen</creatorcontrib><creatorcontrib>Huang, Xiang‐Zhong</creatorcontrib><creatorcontrib>Li, Gan‐Peng</creatorcontrib><creatorcontrib>Jiang, Zhi‐Yong</creatorcontrib><creatorcontrib>Xue, Da‐Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Lu</au><au>Zhou, Jun</au><au>Zhu, Le‐Yu</au><au>Zhang, Juan‐Rong</au><au>Jing, Yu‐Xing</au><au>Zhao, Jia‐Wen</au><au>Huang, Xiang‐Zhong</au><au>Li, Gan‐Peng</au><au>Jiang, Zhi‐Yong</au><au>Xue, Da‐Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Four New Diterpene Glucosides from Perovskia atriplicifolia</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chem Biodivers</addtitle><date>2017-07</date><risdate>2017</risdate><volume>14</volume><issue>7</issue><epage>n/a</epage><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>Four new diterpene glucosides, namely perovskiaditerpenosides A – D (1 – 4), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.</abstract><cop>Switzerland</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28419767</pmid><doi>10.1002/cbdv.201700071</doi><tpages>7</tpages></addata></record> |
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| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Butanols Cell Line, Tumor Cytotoxic activities Cytotoxicity Diterpene glucosides Diterpenes - isolation & purification Drug Screening Assays, Antitumor Glucosides Glucosides - isolation & purification Humans Infrared spectroscopy Labiatae Lamiaceae - chemistry Molecular Structure NMR Nuclear magnetic resonance Perovskia atriplicifolia Perovskiaditerpenosides A – D Plant Extracts Spectroscopic analysis Spectrum Analysis |
| title | Four New Diterpene Glucosides from Perovskia atriplicifolia |
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