Role of MMP-7 in the pathogenesis of systemic lupus erythematosus (SLE)

Role of MMP-7 in the pathogenesis of systemic lupus erythematosus (SLE)

Systemic lupus erythematosus (SLE) is a clinically heterogeneous chronic, inflammatory autoimmune disorder. The association of MMP-7 and disease severity is still unclear. A total of 150 SLE patients and matched healthy controls were recruited for this study. Disease activity was scored according to...

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Veröffentlicht in:Lupus 2017-08, Vol.26 (9), p.937-943
Hauptverfasser: Vira, H, Pradhan, V, Umare, V, Chaudhary, A, Rajadhyksha, A, Nadkar, M, Ghosh, K, Nadkarni, A
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Alleles
Autoantibodies - blood
Autoantibodies - genetics
Female
Genotype
Humans
India - epidemiology
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Lupus Nephritis - blood
Male
Matrix Metalloproteinase 7 - blood
Matrix Metalloproteinase 7 - genetics
Polymorphism, Genetic - genetics
RNA, Messenger - genetics
Severity of Illness Index
Young Adult
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Zusammenfassung:Systemic lupus erythematosus (SLE) is a clinically heterogeneous chronic, inflammatory autoimmune disorder. The association of MMP-7 and disease severity is still unclear. A total of 150 SLE patients and matched healthy controls were recruited for this study. Disease activity was scored according to SLEDAI (98 active and 52 inactive disease). Mean serum MMP-7 levels were significantly higher in SLE patients than controls (p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203316682855