Osteoinductive composite coatings for flexible intramedullary nails
This work presents composite coatings based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) for flexible intramedullary nails (FIN). The effect of the proportion of VDF-TeFE (100–25% wt.) on physicochemical and biological properties of the composite...
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| Veröffentlicht in: | Materials Science & Engineering C 2017-06, Vol.75, p.207-220 |
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| creator | Bolbasov, E.N. Popkov, A.V. Popkov, D.A. Gorbach, E.N. Khlusov, I.A. Golovkin, A.S. Sinev, A. Bouznik, V.M. Tverdokhlebov, S.I. Anissimov, Y.G. |
| description | This work presents composite coatings based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) for flexible intramedullary nails (FIN). The effect of the proportion of VDF-TeFE (100–25% wt.) on physicochemical and biological properties of the composite coatings was investigated. It was shown that a decrease of VDF-TeFE in the coating hinders its crystallization in β and γ forms which have piezoelectric properties. The decrease also reduces an adhesive strength to 9.9±2.4MPa and a relative elongation to 5.9±1.2%, but results in increased osteogenesis. It was demonstrated that the composite coatings with 35% VDF-TeFE has the required combination of physicochemical properties and osteogenic activity. Comparative studies of composite coatings (35% VDF-TeFE) and calcium phosphate coatings produced using micro-arc oxidation, demonstrated comparable results for strength of bonding of these FINs with trabecular bones (~530MPa). It was hypothesized that the high osteoinductive properties of the composite coatings are due to their piezoelectric properties.
[Display omitted]
•VDF-TeFE copolymer/HA composite coatings for flexible intramedullary nail were designed.•The influence of the amount of VDF-TeFE on properties of composites was studied.•VDF-TeFE has electrical activity phases regardless of its content in the composite.•Osteoinductive properties, likely is caused by piezoelectric properties of the composite. |
| doi_str_mv | 10.1016/j.msec.2017.02.073 |
| format | Article |
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[Display omitted]
•VDF-TeFE copolymer/HA composite coatings for flexible intramedullary nail were designed.•The influence of the amount of VDF-TeFE on properties of composites was studied.•VDF-TeFE has electrical activity phases regardless of its content in the composite.•Osteoinductive properties, likely is caused by piezoelectric properties of the composite.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2017.02.073</identifier><identifier>PMID: 28415456</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adhesive bonding ; Adhesive strength ; Animals ; Biocompatibility ; Biological effects ; Biological properties ; Bonding strength ; Bone Nails ; Bone Regeneration ; Bones ; Calcium ; Calcium phosphates ; Coated Materials, Biocompatible - chemistry ; Coatings ; Comparative studies ; Copolymers ; Crystallization ; Dogs ; Durapatite - chemistry ; Elongation ; Female ; Fins ; Flexible intramedullary nail ; Fluorides ; Fluorocarbons - chemistry ; Humans ; Hydroxyapatite ; Intramedullary nails ; Male ; Materials science ; Materials Testing ; Nails ; Osteogenesis ; Oxidation ; Phosphate coatings ; Phosphates ; Physicochemical properties ; Piezoelectric ; Piezoelectricity ; Surgical implants ; Tetrafluoroethylene ; Vinyl Compounds - chemistry ; Vinylidene ; Vinylidene fluoride ; Vinylidene fluoride − tetrafluoroethylene copolymer</subject><ispartof>Materials Science & Engineering C, 2017-06, Vol.75, p.207-220</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jun 1, 2017</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-32e870cc31944de53d31cfed00a4417dd98ba5495c19d0774a329825500d9e0a3</citedby><cites>FETCH-LOGICAL-c384t-32e870cc31944de53d31cfed00a4417dd98ba5495c19d0774a329825500d9e0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2017.02.073$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28415456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bolbasov, E.N.</creatorcontrib><creatorcontrib>Popkov, A.V.</creatorcontrib><creatorcontrib>Popkov, D.A.</creatorcontrib><creatorcontrib>Gorbach, E.N.</creatorcontrib><creatorcontrib>Khlusov, I.A.</creatorcontrib><creatorcontrib>Golovkin, A.S.</creatorcontrib><creatorcontrib>Sinev, A.</creatorcontrib><creatorcontrib>Bouznik, V.M.</creatorcontrib><creatorcontrib>Tverdokhlebov, S.I.</creatorcontrib><creatorcontrib>Anissimov, Y.G.</creatorcontrib><title>Osteoinductive composite coatings for flexible intramedullary nails</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>This work presents composite coatings based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) for flexible intramedullary nails (FIN). The effect of the proportion of VDF-TeFE (100–25% wt.) on physicochemical and biological properties of the composite coatings was investigated. It was shown that a decrease of VDF-TeFE in the coating hinders its crystallization in β and γ forms which have piezoelectric properties. The decrease also reduces an adhesive strength to 9.9±2.4MPa and a relative elongation to 5.9±1.2%, but results in increased osteogenesis. It was demonstrated that the composite coatings with 35% VDF-TeFE has the required combination of physicochemical properties and osteogenic activity. Comparative studies of composite coatings (35% VDF-TeFE) and calcium phosphate coatings produced using micro-arc oxidation, demonstrated comparable results for strength of bonding of these FINs with trabecular bones (~530MPa). It was hypothesized that the high osteoinductive properties of the composite coatings are due to their piezoelectric properties.
[Display omitted]
•VDF-TeFE copolymer/HA composite coatings for flexible intramedullary nail were designed.•The influence of the amount of VDF-TeFE on properties of composites was studied.•VDF-TeFE has electrical activity phases regardless of its content in the composite.•Osteoinductive properties, likely is caused by piezoelectric properties of the composite.</description><subject>Adhesive bonding</subject><subject>Adhesive strength</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biological effects</subject><subject>Biological properties</subject><subject>Bonding strength</subject><subject>Bone Nails</subject><subject>Bone Regeneration</subject><subject>Bones</subject><subject>Calcium</subject><subject>Calcium phosphates</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coatings</subject><subject>Comparative studies</subject><subject>Copolymers</subject><subject>Crystallization</subject><subject>Dogs</subject><subject>Durapatite - chemistry</subject><subject>Elongation</subject><subject>Female</subject><subject>Fins</subject><subject>Flexible intramedullary nail</subject><subject>Fluorides</subject><subject>Fluorocarbons - chemistry</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Intramedullary nails</subject><subject>Male</subject><subject>Materials science</subject><subject>Materials Testing</subject><subject>Nails</subject><subject>Osteogenesis</subject><subject>Oxidation</subject><subject>Phosphate coatings</subject><subject>Phosphates</subject><subject>Physicochemical properties</subject><subject>Piezoelectric</subject><subject>Piezoelectricity</subject><subject>Surgical implants</subject><subject>Tetrafluoroethylene</subject><subject>Vinyl Compounds - chemistry</subject><subject>Vinylidene</subject><subject>Vinylidene fluoride</subject><subject>Vinylidene fluoride − tetrafluoroethylene copolymer</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLFuFDEQhq2IKLkEXoACrURDs8uM7T3bEg06AUGKlAZqy2fPIp9214e9G5G3x6cLFBRUM8U3_8x8jL1G6BBw-_7QTYV8xwFVB7wDJS7YBrUSLaDBF2wDhutWGoHX7KaUA8BWC8Wv2DXXEnvZbzds91AWSnEOq1_iIzU-TcdU4nLq3BLnH6UZUm6GkX7F_UhNnJfsJgrrOLr81MwujuUluxzcWOjVc71l3z9_-ra7a-8fvnzdfbxvvdByaQUnrcB7gUbKQL0IAv1AAcBJiSoEo_eul6b3aAIoJZ3gRvO-BwiGwIlb9u6ce8zp50plsVMsnuolM6W1WNTa1E1oeEXf_oMe0prnep2t27mSUgmsFD9TPqdSMg32mONU_7II9qTYHuxJsT0ptsBtVVyH3jxHr_sq4u_IH6cV-HAGqLp4jJRt8ZFmTyFm8osNKf4v_ze_PYww</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Bolbasov, E.N.</creator><creator>Popkov, A.V.</creator><creator>Popkov, D.A.</creator><creator>Gorbach, E.N.</creator><creator>Khlusov, I.A.</creator><creator>Golovkin, A.S.</creator><creator>Sinev, A.</creator><creator>Bouznik, V.M.</creator><creator>Tverdokhlebov, S.I.</creator><creator>Anissimov, Y.G.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Osteoinductive composite coatings for flexible intramedullary nails</title><author>Bolbasov, E.N. ; Popkov, A.V. ; Popkov, D.A. ; Gorbach, E.N. ; Khlusov, I.A. ; Golovkin, A.S. ; Sinev, A. ; Bouznik, V.M. ; Tverdokhlebov, S.I. ; Anissimov, Y.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-32e870cc31944de53d31cfed00a4417dd98ba5495c19d0774a329825500d9e0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adhesive bonding</topic><topic>Adhesive strength</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biological effects</topic><topic>Biological properties</topic><topic>Bonding strength</topic><topic>Bone Nails</topic><topic>Bone Regeneration</topic><topic>Bones</topic><topic>Calcium</topic><topic>Calcium phosphates</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Coatings</topic><topic>Comparative studies</topic><topic>Copolymers</topic><topic>Crystallization</topic><topic>Dogs</topic><topic>Durapatite - chemistry</topic><topic>Elongation</topic><topic>Female</topic><topic>Fins</topic><topic>Flexible intramedullary nail</topic><topic>Fluorides</topic><topic>Fluorocarbons - chemistry</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Intramedullary nails</topic><topic>Male</topic><topic>Materials science</topic><topic>Materials Testing</topic><topic>Nails</topic><topic>Osteogenesis</topic><topic>Oxidation</topic><topic>Phosphate coatings</topic><topic>Phosphates</topic><topic>Physicochemical properties</topic><topic>Piezoelectric</topic><topic>Piezoelectricity</topic><topic>Surgical implants</topic><topic>Tetrafluoroethylene</topic><topic>Vinyl Compounds - chemistry</topic><topic>Vinylidene</topic><topic>Vinylidene fluoride</topic><topic>Vinylidene fluoride − tetrafluoroethylene copolymer</topic><toplevel>online_resources</toplevel><creatorcontrib>Bolbasov, E.N.</creatorcontrib><creatorcontrib>Popkov, A.V.</creatorcontrib><creatorcontrib>Popkov, D.A.</creatorcontrib><creatorcontrib>Gorbach, E.N.</creatorcontrib><creatorcontrib>Khlusov, I.A.</creatorcontrib><creatorcontrib>Golovkin, A.S.</creatorcontrib><creatorcontrib>Sinev, A.</creatorcontrib><creatorcontrib>Bouznik, V.M.</creatorcontrib><creatorcontrib>Tverdokhlebov, S.I.</creatorcontrib><creatorcontrib>Anissimov, Y.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bolbasov, E.N.</au><au>Popkov, A.V.</au><au>Popkov, D.A.</au><au>Gorbach, E.N.</au><au>Khlusov, I.A.</au><au>Golovkin, A.S.</au><au>Sinev, A.</au><au>Bouznik, V.M.</au><au>Tverdokhlebov, S.I.</au><au>Anissimov, Y.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteoinductive composite coatings for flexible intramedullary nails</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>75</volume><spage>207</spage><epage>220</epage><pages>207-220</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>This work presents composite coatings based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) for flexible intramedullary nails (FIN). The effect of the proportion of VDF-TeFE (100–25% wt.) on physicochemical and biological properties of the composite coatings was investigated. It was shown that a decrease of VDF-TeFE in the coating hinders its crystallization in β and γ forms which have piezoelectric properties. The decrease also reduces an adhesive strength to 9.9±2.4MPa and a relative elongation to 5.9±1.2%, but results in increased osteogenesis. It was demonstrated that the composite coatings with 35% VDF-TeFE has the required combination of physicochemical properties and osteogenic activity. Comparative studies of composite coatings (35% VDF-TeFE) and calcium phosphate coatings produced using micro-arc oxidation, demonstrated comparable results for strength of bonding of these FINs with trabecular bones (~530MPa). It was hypothesized that the high osteoinductive properties of the composite coatings are due to their piezoelectric properties.
[Display omitted]
•VDF-TeFE copolymer/HA composite coatings for flexible intramedullary nail were designed.•The influence of the amount of VDF-TeFE on properties of composites was studied.•VDF-TeFE has electrical activity phases regardless of its content in the composite.•Osteoinductive properties, likely is caused by piezoelectric properties of the composite.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28415456</pmid><doi>10.1016/j.msec.2017.02.073</doi><tpages>14</tpages></addata></record> |
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| subjects | Adhesive bonding Adhesive strength Animals Biocompatibility Biological effects Biological properties Bonding strength Bone Nails Bone Regeneration Bones Calcium Calcium phosphates Coated Materials, Biocompatible - chemistry Coatings Comparative studies Copolymers Crystallization Dogs Durapatite - chemistry Elongation Female Fins Flexible intramedullary nail Fluorides Fluorocarbons - chemistry Humans Hydroxyapatite Intramedullary nails Male Materials science Materials Testing Nails Osteogenesis Oxidation Phosphate coatings Phosphates Physicochemical properties Piezoelectric Piezoelectricity Surgical implants Tetrafluoroethylene Vinyl Compounds - chemistry Vinylidene Vinylidene fluoride Vinylidene fluoride − tetrafluoroethylene copolymer |
| title | Osteoinductive composite coatings for flexible intramedullary nails |
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