Baicalein increases cisplatin sensitivity of A549 lung adenocarcinoma cells via PI3K/Akt/NF-κB pathway

Baicalein increases cisplatin sensitivity of A549 lung adenocarcinoma cells via PI3K/Akt/NF-κB pathway

Highlights • Baicalein significantly enhanced the sensitivity of cisplatin in vivo and in vitro. • Baicalein enhanced the sensitivity of cisplatin by via EMT and apoptosis. • Baicalein reversed EMT and attenuated apoptosis via PI3K/Akt/NF-κB pathway. • Baicalein may overcome acquired resistance to c...

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Veröffentlicht in:Biomedicine & pharmacotherapy 2017-06, Vol.90, p.677-685
Hauptverfasser: Yu, Meiling, Qi, Benquan, Xiaoxiang, Wu, Xu, Jian, Liu, Xiaolin
Format: Artikel
Sprache:eng
Schlagworte:
A549 Cells - drug effects
A549 Cells - metabolism
Adenocarcinoma - drug therapy
Adenocarcinoma - metabolism
Adenocarcinoma of Lung
Animals
Baicalein
Cell Line, Tumor
Cisplatin
Cisplatin - pharmacology
Epithelial-mesenchymal transition
Flavanones - pharmacology
Humans
Internal Medicine
Lung Neoplasms - drug therapy
Lung Neoplasms - metabolism
Medical Education
NF-kappa B - metabolism
Phosphatidylinositol 3-Kinases - metabolism
PI3K/Akt/NF-κB pathway
Proto-Oncogene Proteins c-akt - metabolism
Signal Transduction - drug effects
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Zusammenfassung:Highlights • Baicalein significantly enhanced the sensitivity of cisplatin in vivo and in vitro. • Baicalein enhanced the sensitivity of cisplatin by via EMT and apoptosis. • Baicalein reversed EMT and attenuated apoptosis via PI3K/Akt/NF-κB pathway. • Baicalein may overcome acquired resistance to chemotherapy.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.04.001