Histological assessment of skin damage by irritants: its possible use in the evaluation of a 'barrier cream'

The histological changes induced by topical application of selected irritants are reported. The possible application of this methodology to the evaluation of the protective value of a silicone‐containing barrier cream is discussed. Although this crude method only allows objectivity of the later stag...

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Veröffentlicht in:	Contact dermatitis 1984-08, Vol.11 (3), p.179-185
Hauptverfasser:	Mahmoud, G., Lachapelle, J. M., van Neste, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals barrier cream Biological and medical sciences dermatitis (contact) Drug Evaluation Emulsions - administration & dosage epidermis experimental dermatology Female Guinea Pigs Irritants - adverse effects irritation Medical sciences Mineral Oil - adverse effects Ointments Pharmacology. Drug treatments silicone Silicones - administration & dosage Siloxanes - administration & dosage Skin - pathology Skin Diseases - pathology Skin Diseases - prevention & control Skin, nail, hair, dermoskeleton Sodium Dodecyl Sulfate - adverse effects Sodium Hydroxide - adverse effects Stevens-Johnson Syndrome - etiology Stevens-Johnson Syndrome - prevention & control Toluene - adverse effects
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Beschreibung
Zusammenfassung:	The histological changes induced by topical application of selected irritants are reported. The possible application of this methodology to the evaluation of the protective value of a silicone‐containing barrier cream is discussed. Although this crude method only allows objectivity of the later stages of a toxic reaction, it gives useful information about the potential protective effect of a silicone‐containing barrier cream.
ISSN:	0105-1873 1600-0536
DOI:	10.1111/j.1600-0536.1984.tb00967.x