Cutting Edge in IFN Regulation: Inflammatory Caspases Cleave cGAS

Caspases have important functions beyond their established role in driving inflammation and apoptosis. In this issue of Immunity, Wang et al. (2017) demonstrate that inflammasome-triggered caspases cleave and inactivate the DNA sensor cGAS, thus restricting the type I interferon response to cytosoli...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2017-03, Vol.46 (3), p.333-335
Hauptverfasser:	Heidegger, Simon, Haas, Tobias, Poeck, Hendrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Caspases Cytosol - immunology Deoxyribonucleic acid DNA Humans Immunity Infections Inflammasomes Inflammation Interferon Interferon Type I Kinases Nucleotidyltransferases - genetics Proteins Viral infections Viruses
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Zusammenfassung:	Caspases have important functions beyond their established role in driving inflammation and apoptosis. In this issue of Immunity, Wang et al. (2017) demonstrate that inflammasome-triggered caspases cleave and inactivate the DNA sensor cGAS, thus restricting the type I interferon response to cytosolic DNA. Caspases have important functions beyond their established role in driving inflammation and apoptosis. Wang et al. (2017) demonstrate that inflammasome-triggered caspases cleave and inactivate the DNA sensor cGAS, thus restricting the type I interferon response to cytosolic DNA.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2017.03.004