Desensitization to DNFB in hairless mice

Desensitization to DNFB in hairless mice

Naive hairless mice may be rendered partly tolerant to dinitrofluorobenzene (DNFB) by painting UNFB on skin irradiated with 30 mJ·cm−2 ultraviolet B light (UVB) over 4 days. However, DNFB‐sensitized hairless mice show no decrease in sensitivity when repainted with DNFB on skin irradiated with the sa...

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Veröffentlicht in:Contact dermatitis 1987-09, Vol.17 (3), p.146-148
1. Verfasser: Copeman, M. C.
Format: Artikel
Sprache:eng
Schlagworte:
Allergic diseases
Animals
Biological and medical sciences
contact hypersensitivity
Dermatitis, Contact - immunology
Dermatitis, Contact - radiotherapy
Desensitization, Immunologic
Dinitrofluorobenzene - adverse effects
Female
Hairless mice
Immune Tolerance
Immunopathology
Male
Medical sciences
Mice
Mice, Hairless
Nitrobenzenes - adverse effects
Skin allergic diseases. Stinging insect allergies
ultraviolet B irradiation
Ultraviolet Therapy
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Beschreibung
Zusammenfassung:Naive hairless mice may be rendered partly tolerant to dinitrofluorobenzene (DNFB) by painting UNFB on skin irradiated with 30 mJ·cm−2 ultraviolet B light (UVB) over 4 days. However, DNFB‐sensitized hairless mice show no decrease in sensitivity when repainted with DNFB on skin irradiated with the same dose of UVB. Hence, established hypersensitivity appears not lo be reduced by this method of inducing tolerance in nuive mice.
ISSN:0105-1873
1600-0536
DOI:10.1111/j.1600-0536.1987.tb02694.x