Myeloid but not plasmacytoid blood DCs possess Th1 polarizing and Th1/Th17 recruiting capacity in psoriasis

Highlights • Psoriatic blood mDCs express CD83/CD86 maturation/activation markers. • Psoriatic blood mDCs are able to produce IL-12 Th1-polarizing cytokine. • Psoriatic blood mDCs can produce CXCL9 and CCL20 Th1/Th17 recruiting chemokines. • Psoriatic blood plasmacytoid DCs exhibit resting phenotype...

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Veröffentlicht in:	Immunology letters 2017-09, Vol.189, p.109-113
Hauptverfasser:	Khasawneh, Ahmed, Baráth, Sándor, Medgyesi, Barbara, Béke, Gabriella, Dajnoki, Zsolt, Gáspár, Krisztián, Jenei, Adrienn, Pogácsás, Lilla, Pázmándi, Kitti, Gaál, János, Bácsi, Attila, Szegedi, Andrea, Kapitány, Anikó
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergy and Immunology Antigens, CD1 - metabolism Cell Differentiation Cell surface marker Cells, Cultured Chemokine Chemokine CCL20 - metabolism Chemokine CXCL9 - metabolism Cytokines - metabolism Dendritic cell Dendritic Cells - physiology Female Humans Male Middle Aged Myeloid Cells - physiology Psoriasis Psoriasis - immunology Skin - immunology T cell polarizing cytokine Th1 Cells - immunology Th17 Cells - immunology
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Zusammenfassung:	Highlights • Psoriatic blood mDCs express CD83/CD86 maturation/activation markers. • Psoriatic blood mDCs are able to produce IL-12 Th1-polarizing cytokine. • Psoriatic blood mDCs can produce CXCL9 and CCL20 Th1/Th17 recruiting chemokines. • Psoriatic blood plasmacytoid DCs exhibit resting phenotype
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2017.04.005