Diterpenoid Alkaloids as Antidotes to Aconitine-Type Neurotoxin Poisoning. Structure–Activity Relationship

Diterpenoid Alkaloids as Antidotes to Aconitine-Type Neurotoxin Poisoning. Structure–Activity Relationship

The in vivo antidote activity of 72 diterpenoid alkaloids isolated from plants of the genera Aconitum, Delphinium, and Consolida and their derivatives was tested against poisoning of mice by a lethal dose of aconitine. The structure–activity relationship was analyzed. The use of diterpenoid alkaloid...

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Veröffentlicht in:Chemistry of natural compounds 2016-09, Vol.52 (5), p.849-852
Hauptverfasser: Tursunkhodzhaeva, F. M., Dzhakhangirov, F. N., Salimov, B. T.
Format: Artikel
Sprache:eng
Schlagworte:
Aconitum
Alkaloids
Antidotes
Consolida
Delphinium
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
Poisoning
Toxins
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Zusammenfassung:The in vivo antidote activity of 72 diterpenoid alkaloids isolated from plants of the genera Aconitum, Delphinium, and Consolida and their derivatives was tested against poisoning of mice by a lethal dose of aconitine. The structure–activity relationship was analyzed. The use of diterpenoid alkaloids as versatile antidotes against poisoning of animals and humans by aconitine-, veratridine-, and batrachotoxin-type neurotoxins was justified.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-016-1794-1