Cobalt(III) complexes with biguanide derivatives: Synthesis, structures, and antiviral activity

Cobalt(III) complexes with biguanide derivatives: Synthesis, structures, and antiviral activity

Three Co(III) complexes with biguanide derivatives [Co(NH 2 C(=NH)NHC(=NH)NR 1 R 2 ) 3 ]Cl 3 (R 1 R 2 = Me 2 ( I ), Et 2 ( II ), and H s Bu ( III )) were obtained and characterized by elemental analysis, IR spectroscopy, and electronic absorption spectroscopy. Structure III was confirmed by X-ray di...

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Veröffentlicht in:Russian journal of coordination chemistry 2016-04, Vol.42 (4), p.260-266
Hauptverfasser: Kirin, V. P., Demkin, A. G., Smolentsev, A. I., Il’icheva, T. N., Maksakov, V. A.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Orthomyxoviridae
Physical Chemistry
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Zusammenfassung:Three Co(III) complexes with biguanide derivatives [Co(NH 2 C(=NH)NHC(=NH)NR 1 R 2 ) 3 ]Cl 3 (R 1 R 2 = Me 2 ( I ), Et 2 ( II ), and H s Bu ( III )) were obtained and characterized by elemental analysis, IR spectroscopy, and electronic absorption spectroscopy. Structure III was confirmed by X-ray diffraction (CIF file CCDC no. 1401783). Complexes I–III and [M(SC(NH 2 ) 2 ) 4 ]Cl 2 (M = Pd, Pt, and [Co(En) 3 ]Cl 3 ) were tested for in vitro antiviral activity against the A/California/07/09 (H1N1pdm09) influenza virus. The best results were achieved with complex III and both thiourea complexes.
ISSN:1070-3284
1608-3318
DOI:10.1134/S1070328416040023