Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the in...

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Veröffentlicht in:	Russian journal of bioorganic chemistry 2016-07, Vol.42 (4), p.423-427
Hauptverfasser:	Grigorenko, N. A., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Khomutov, A. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Life Sciences Organic Chemistry
Online-Zugang:	Volltext
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