Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the in...

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Veröffentlicht in:Russian journal of bioorganic chemistry 2016-07, Vol.42 (4), p.423-427
Hauptverfasser: Grigorenko, N. A., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Khomutov, A. R.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Organic Chemistry
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Zusammenfassung:Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162016030080