Primary tumor resection does not improve survival among patients with unresectable colorectal cancer metastases—But who determines resectability?

Conclusive data do not support routine asymptomatic, primary tumor resection among patients with unresectable colorectal cancer metastases. However, the authors strongly caution against an extrapolation of this conclusion that deters patients with stage IV disease from being referred for consideration of potentially curative metastasectomy.